// Weight Loss
GLP-1s changed
what's possible.
For decades, sustained weight loss was a coin flip — willpower against biology. Biology usually won. A new class of medications changes the math. They work on the same hunger and satiety signals your body already uses, just louder and longer.
How this works in your body
After you eat, your gut releases a hormone called GLP-1. It tells your pancreas to release insulin, slows stomach emptying, and tells your brain you've had enough. In many people that signal is weak or short-lived. GLP-1 medications are synthetic versions that last days instead of minutes. Some — like tirzepatide — also activate a second hormone, GIP, which seems to amplify the effect. You'll notice smaller portions feel like enough. The constant background hum of "what's next to eat" — what patients call food noise — quiets down.
Who does well
Adults with a BMI over 27 who have tried calorie restriction and found it unsustainable. People with type 2 diabetes or pre-diabetes. Patients frustrated by diets that worked short-term but rebounded.
Who should wait
Personal or family history of medullary thyroid cancer. Pregnancy or breastfeeding. Active gallbladder disease. History of pancreatitis. Your provider will screen for these during your intake.
What timelines actually look like
Most patients lose 5–10% of starting weight in the first 3 months, 15–20% by month 6–9 on an optimal dose. Weight loss is not linear — expect plateaus. Side effects (nausea, constipation) are most common the week after each dose increase and fade with time.
Prescription required. Reviewed by a licensed U.S. physician. Compounded by Greenstone Rx, a Florida 503A pharmacy. Full disclaimer.